Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under immunosuppressive therapy

Takehiko Mori, Hideto Kameda, Hiroe Ogawa, Atsushi Iizuka, Naoya Sekiguchi, Hirofumi Takei, Hayato Nagasawa, Michihide Tokuhira, Toshio Tanaka, Yumiko Saito, Koichi Amano, Toru Abe, Tsutomu Takeuchi

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Objective. To evaluate the incidence and effect of cytomegalovirus (CMV) reactivation in patients with inflammatory connective tissue diseases (CTD) undergoing immunosuppressive therapy. Methods. A total of 18 consecutive CMV seropositive patients undergoing immunosuppressive therapy for inflammatory CTD were enrolled. CMV reactivation was determined by detection of CMV-DNA in peripheral blood leukocytes (PBL) or plasma using quantitative real-time polymerase chain reaction. Results. CMV reactivation was detected in PBL in 7 of 17 evaluable patients (41%), and in plasma in 5 of 17 patients (29%). Patients with detectable CMV-DNA in plasma were exclusively positive for CMV-DNA in PBL. Conclusion. Patients with inflammatory CTD under immunosuppressive therapy are at high risk for CMV reactivation. The clinical significance of such an event and indications for antiviral therapy should be examined further.

本文言語English
ページ(範囲)1349-1351
ページ数3
ジャーナルJournal of Rheumatology
31
7
出版ステータスPublished - 2004 7 1

ASJC Scopus subject areas

  • リウマチ学
  • 免疫アレルギー学
  • 免疫学

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