Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation

Chiaki Nakaseko, Shinichi Ozawa, Emiko Sakaida, Miwa Sakai, Yoshinobu Kanda, Kumi Oshima, Mineo Kurokawa, Satoshi Takahashi, Jun Ooi, Takayuki Shimizu, Akira Yokota, Fumiaki Yoshiba, Katsumichi Fujimaki, Heiwa Kanamori, Rika Sakai, Takayuki Saitoh, Tohru Sakura, Atsuo Maruta, Hisashi Sakamaki, Shinichiro Okamoto

研究成果: Article

39 引用 (Scopus)

抜粋

Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life. We retrospectively analysed the incidence of and risk factors for BO in allo-SCT recipients. In 2087 patients who underwent allo-SCT between January 1994 and June 2005 and survived >90 days after transplantation, 57 patients developed BO with a 5-year cumulative incidence of 2.8%. The median time interval from transplantation to BO diagnosis was 335 days (range 83-907 days). The 5-year cumulative incidence of BO was 1.62% in bone marrow transplantation (BMT) from related donors, 3.83% in peripheral blood stem cell transplantation (PBSCT) from related donors (R-PBSCT), 2.91% in BMT from unrelated donors and 2.65% in unrelated cord blood transplantation. The incidence of BO after R-PBSCT was significantly higher than that after any other type of allo-SCT (p = 0.02). R-PBSCT (p = 0.019) and preceding chronic graft-versus-host disease (GVHD) (p < 0.001) were BO-associated risk factors. Overall 5-year survival of patients with BO from the time of diagnosis was 45.4%, significantly less than those without (77.5% from day 335, p < 0.001). R-PBSCT recipients with existent chronic GVHD have a high risk of developing BO, and need extensive care and repeated pulmonary function tests.

元の言語English
ページ(範囲)375-382
ページ数8
ジャーナルInternational journal of hematology
93
発行部数3
DOI
出版物ステータスPublished - 2011 3

ASJC Scopus subject areas

  • Hematology

フィンガープリント Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Nakaseko, C., Ozawa, S., Sakaida, E., Sakai, M., Kanda, Y., Oshima, K., Kurokawa, M., Takahashi, S., Ooi, J., Shimizu, T., Yokota, A., Yoshiba, F., Fujimaki, K., Kanamori, H., Sakai, R., Saitoh, T., Sakura, T., Maruta, A., Sakamaki, H., & Okamoto, S. (2011). Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation. International journal of hematology, 93(3), 375-382. https://doi.org/10.1007/s12185-011-0809-8