Incomplete Androgen Insensitivity Associated with a Thermolabile Androgen Receptor

Tomonobu Hasegawa, Yukihiro Hasegawa, Taiji Aso, Shinobu Koto, Yutaka Tsuchiya

研究成果: Article査読

3 被引用数 (Scopus)

抄録

One infant and a cousin with incomplete androgen insensitivity syndrome were reported. The familial pedigree showed that the disorder was inherited in three generations in X-linked recessive fashion. An androgen binding study of cultured genital skin fibroblast from patients showed normal maximum binding capacity and a normal apparent dissociation constant. Heat stability assay showed binding decreased to less than 30% at 41 °C compared with the amount at 30°C, indicating that the androgen receptor was thermolabile.

本文言語English
ページ(範囲)31-35
ページ数5
ジャーナルEndocrine journal
41
1
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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