Increase in synthesis and stability of σ32 on treatment with inhibitors of DNA gyrase in Escherichia coli

T. Mizushima, Y. Ohtsuka, H. Mori, T. Miki, K. Sekimizu

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We report here that in Escherichia coli, the anti-bacterial agent nalidixic acid induces transient stabilization and increased synthesis of σ32, accompanied by the induction of heat shock proteins (Dnak and GroEL proteins). The induction of heat shock proteins, increased synthesis of σ32, and stabilization of σ32 observed on treatment of wild-type cells with nalidixic acid were not observed in a nalA26 mutant, a strain that is resistant to nalidixic acid as the result of a mutation in the gyrA gene. Not only oxolinic acid, but also novobiocin, whose targets are the A and B subunits of DNA gyrase, respectively, also induced stabilization and increased synthesis of σ32. Thus, inhibition of the activity of DNA gyrase may cause stabilization and increased synthesis of σ32, resulting in turn in induction of heat shock proteins.

本文言語English
ページ(範囲)297-302
ページ数6
ジャーナルMolecular Genetics and Genomics
253
3
出版ステータスPublished - 1996 12月 13

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学

フィンガープリント

「Increase in synthesis and stability of σ32 on treatment with inhibitors of DNA gyrase in Escherichia coli」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル