Increase in thalamic binding of [11C]PE2I in patients with schizophrenia: A positron emission tomography study of dopamine transporter

Ryosuke Arakawa, Tetsuya Ichimiya, Hiroshi Ito, Akihiro Takano, Masaki Okumura, Hidehiko Takahashi, Harumasa Takano, Fumihiko Yasuno, Motoichiro Kato, Yoshiro Okubo, Tetsuya Suhara

研究成果: Article

30 引用 (Scopus)

抄録

Previous in vivo imaging studies reported no difference in dopamine transporter (DAT) bindings in the striatum between control subjects and patients with schizophrenia. However, as the signals of radioligands with moderate affinity were insufficient for allowing the evaluation of small amounts of DAT, DAT binding in extrastriatal regions has not been determined. Positron emission tomography scanning using [11C]PE2I was performed on eight patients with schizophrenia and twelve normal control subjects. Binding potential (BPND) for DAT in the caudate, putamen, thalamus and substantia nigra was calculated, using the cerebellum as reference region. In patients with schizophrenia, clinical symptoms were evaluated by Positive and Negative Syndrome Scale (PANSS). BPND in the thalamus of patients with schizophrenia was significantly higher than in control subjects (P = 0.044). In patients with schizophrenia, there were significantly positive correlations between BPND in the thalamus and total (r = 0.75), positive (r = 0.78) and negative PANSS scores (r = 0.82). Altered DAT in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia.

元の言語English
ページ(範囲)1219-1223
ページ数5
ジャーナルJournal of Psychiatric Research
43
発行部数15
DOI
出版物ステータスPublished - 2009 10

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Dopamine Plasma Membrane Transport Proteins
Positron-Emission Tomography
Schizophrenia
Thalamus
Putamen
Substantia Nigra
Cerebellum
N-(3-iodoprop-2-enyl)-2-beta-carbomethoxy-3-(4-methylphenyl)nortropane

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Increase in thalamic binding of [11C]PE2I in patients with schizophrenia : A positron emission tomography study of dopamine transporter. / Arakawa, Ryosuke; Ichimiya, Tetsuya; Ito, Hiroshi; Takano, Akihiro; Okumura, Masaki; Takahashi, Hidehiko; Takano, Harumasa; Yasuno, Fumihiko; Kato, Motoichiro; Okubo, Yoshiro; Suhara, Tetsuya.

:: Journal of Psychiatric Research, 巻 43, 番号 15, 10.2009, p. 1219-1223.

研究成果: Article

Arakawa, R, Ichimiya, T, Ito, H, Takano, A, Okumura, M, Takahashi, H, Takano, H, Yasuno, F, Kato, M, Okubo, Y & Suhara, T 2009, 'Increase in thalamic binding of [11C]PE2I in patients with schizophrenia: A positron emission tomography study of dopamine transporter', Journal of Psychiatric Research, 巻. 43, 番号 15, pp. 1219-1223. https://doi.org/10.1016/j.jpsychires.2009.04.009
Arakawa, Ryosuke ; Ichimiya, Tetsuya ; Ito, Hiroshi ; Takano, Akihiro ; Okumura, Masaki ; Takahashi, Hidehiko ; Takano, Harumasa ; Yasuno, Fumihiko ; Kato, Motoichiro ; Okubo, Yoshiro ; Suhara, Tetsuya. / Increase in thalamic binding of [11C]PE2I in patients with schizophrenia : A positron emission tomography study of dopamine transporter. :: Journal of Psychiatric Research. 2009 ; 巻 43, 番号 15. pp. 1219-1223.
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