Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

Wolfram Jochum, Jean Pierre David, Candace Elliott, Anton Wutz, Hanns Plenk, Koichi Matsuo, Erwin F. Wagner

研究成果: Article査読

252 被引用数 (Scopus)

抄録

Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.

本文言語English
ページ(範囲)980-984
ページ数5
ジャーナルNature medicine
6
9
DOI
出版ステータスPublished - 2000 9
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル