Increased expression of type VI collagen genes in drug-induced gingival enlargement

Hideo Shikata, Nobuo Utsumi, Takahiro Shimojima, Yoshio Oda, Yasunori Okada

研究成果: Article

15 引用 (Scopus)

抄録

Fibrotic gingival enlargements induced by phenytoin or nifedipine were examined with special reference to type VI collagen expression. Immuno-localization studies showed abnormal accumulation of type VI collagen around the collagen fiber bundles in the fibrotic gingival enlargements. Examination of total RNA extracted from fibroblasts and tissues of enlarged gingivae demonstrated increased type VI collagen steady-state mRNA levels. These results suggest that excessive deposition of type VI collagen in drug-induced gingival enlargement is attributed to increased expression of the collagen genes.

元の言語English
ページ(範囲)65-68
ページ数4
ジャーナルFEBS Letters
334
発行部数1
DOI
出版物ステータスPublished - 1993 11 8

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Collagen Type VI
Genes
Pharmaceutical Preparations
Collagen
Phenytoin
Gingiva
Fibroblasts
Nifedipine
RNA
Tissue
Gene Expression
Messenger RNA
Fibers

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

これを引用

Increased expression of type VI collagen genes in drug-induced gingival enlargement. / Shikata, Hideo; Utsumi, Nobuo; Shimojima, Takahiro; Oda, Yoshio; Okada, Yasunori.

:: FEBS Letters, 巻 334, 番号 1, 08.11.1993, p. 65-68.

研究成果: Article

Shikata, H, Utsumi, N, Shimojima, T, Oda, Y & Okada, Y 1993, 'Increased expression of type VI collagen genes in drug-induced gingival enlargement', FEBS Letters, 巻. 334, 番号 1, pp. 65-68. https://doi.org/10.1016/0014-5793(93)81681-O
Shikata, Hideo ; Utsumi, Nobuo ; Shimojima, Takahiro ; Oda, Yoshio ; Okada, Yasunori. / Increased expression of type VI collagen genes in drug-induced gingival enlargement. :: FEBS Letters. 1993 ; 巻 334, 番号 1. pp. 65-68.
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