Increased levels of Epstein‐Barr virus DNA in lacrimal glands of Sjögren's syndrome patients

Kazuo Tsubota, Hiroshi Fujishima, Ikuko Toda, Shigeo Katagiri, Yasushi Kawashima, Ichiro Saito

研究成果: Article査読

21 被引用数 (Scopus)

抄録

ABSTRACT Many Sjögren's syndrome patients complain primarily of dry eye. Epstein‐Barr virus DNA has recently been found in the lacrimal glands of Sjögren's syndrome sufferers and normal individuals, and lacrimal glands are thought to be a target organ for latent Epstein‐Barr virus infection. In this study, we performed lacrimal and salivary gland biopsies on 9 Sjögren's syndrome patients. Extracted Epstein‐Barr virus DNA was assayed by polymerase chain reaction and compared to that of healthy individuals. An increased level of Epstein‐Barr virus DNA was observed in all of the lacrimal glands and 8 of the 9 salivary glands from the Sjögren's syndrome patients. However, the amount of genome in the lacrimal gland was more than 10 times that in the salivary glands, not only in the Sjögren's syndrome patients but also in the controls. This may explain the pathogenesis of dry eye in patients with Sjögren's syndrome, and why the lacrimal gland tends to be so prominently affected. It may also suggest a therapeutic approach for this and possibly other types of dry eye. 1995 Institution Acta Ophthalmologica Scandinavica

本文言語English
ページ(範囲)425-430
ページ数6
ジャーナルActa Ophthalmologica Scandinavica
73
5
DOI
出版ステータスPublished - 1995 10月

ASJC Scopus subject areas

  • 眼科学

フィンガープリント

「Increased levels of Epstein‐Barr virus DNA in lacrimal glands of Sjögren's syndrome patients」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル