Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease

Sumihiro Maeda, Naruhiko Sahara, Yuko Saito, Shigeo Murayama, Atsushi Ikai, Akihiko Takashima

研究成果: Article査読

207 被引用数 (Scopus)

抄録

Development of neurofibrillary tangles (NFTs) is a pathological hallmark in various neurodegenerative disorders including Alzheimer's disease (AD). Recently, we identified a granular tau oligomer having a pre-filamentous structure. To determine the role of this oligomer in NFT formation, we quantified the amount of granular tau oligomer in 21 frontal cortex samples, each displaying varying degrees of Braak-staged NFT pathology. Here we report that granular tau oligomer levels in frontal cortex were significantly increased, even in brains displaying Braak-stage I neuropathology, a stage at which clinical symptoms of AD and NFTs in frontal cortex are believed to be absent. This suggests that increases in granular tau oligomer levels occur before NFTs form and before individuals manifest clinical symptoms of AD. Increased granular tau oligomer levels, therefore, may lead to NFT formation in frontal cortex, eventually leading to the development of AD. Thus, increases in granular tau oligomer levels may represent a very early sign of NFT formation and AD.

本文言語English
ページ(範囲)197-201
ページ数5
ジャーナルNeuroscience Research
54
3
DOI
出版ステータスPublished - 2006 3 1
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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