Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice

Hitoshi Kajigaya, Kenji F. Tanaka, Akiko Hayashi, Ayaka Suzuki, Tomoko Ishibashi, Kazuhiro Ikenaka, Hiroko Baba

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Sulfatide is a myelin glycolipid that functions in the formation of paranodal axoglial junctions in vivo and in the regulation of oligodendrocyte differentiation in vitro. Cerebroside sulfotransferase (CST) catalyzes the production of two sulfated glycolipids, sulfatide and proligodendroblast antigen, in oligodendrocyte lineage cells. Recent studies have demonstrated significant increases in oligodendrocytes from the myelination stage through adulthood in brain and spinal cord under CST-deficient conditions. However, whether these result from excess migration or in situ proliferation during development is undetermined. In the present study, CST-deficient optic nerves were used to examine migration and proliferation of oligodendrocyte precursor cells (OPCs) under sulfated glycolipid-deficient conditions. In adults, more NG2-positive OPCs and fully differentiated cells were observed. In developing optic nerves, the number of cells at the leading edge of migration was similar in CST-deficient and wild-type mice. However, BrdUD proliferating OPCs were more abundant in CST-deficient mice. These results suggest that sulfated glycolipids may be involved in proliferation of OPCs in vivo.

本文言語English
ページ(範囲)415-424
ページ数10
ジャーナルProceedings of the Japan Academy Series B: Physical and Biological Sciences
87
7
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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