Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

Aki Yamashita, Kei Kawana, Kensuke Tomio, Ayumi Taguchi, Yosuke Isobe, Ryo Iwamoto, Koji Masuda, Hitomi Furuya, Takeshi Nagamatsu, Kazunori Nagasaka, Takahide Arimoto, Katsutoshi Oda, Osamu Wada-Hiraike, Takahiro Yamashita, Yuji Taketani, Jing X. Kang, Shiro Kozuma, Hiroyuki Arai, Makoto Arita, Yutaka OsugaTomoyuki Fujii

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18- hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.

本文言語English
論文番号3113
ジャーナルScientific reports
3
DOI
出版ステータスPublished - 2013
外部発表はい

ASJC Scopus subject areas

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