Increased urinary dopamine excretion in Young patients with essential hypertension

I. Saito, S. Itsuji, E. Takeshita, H. Kawabe, M. Nishino, H. Wainai, C. Hasegawa, T. Saruta, S. Nagano, T. Sekihara

研究成果: Article査読

35 被引用数 (Scopus)

抄録

The evidence that some older patients with essential hypertension have low urinary dopamine excretion has brought into question the levels of urinary dopamine and plasma dopa, the major source of urinary dopamine, in young patients with essential hypertension. Twentyfour-hour urine sodium, creatinine, dopamine and noradrenaline and plasma dopa were evaluated in 48 patients with essential hypertension aged 18 to 27 years and 25 normotensive subjects. In comparison with age-matched normotensive subjects, the hypertensive patients had higher urinary dopamine (1920 ± 80 vs 1520 ± 130 nmol/day, p < 0.01) and noradrenaline (216 ± 11 vs 179 ± 12 nmol/day, p < 0.05) excretion. There was a significant correlation between urinary dopamine and noradrenaline excretion. There was no difference in plasma dopa levels between normotensive and hypertensive subjects. These results suggest that the elevated conversion of dopa to dopamine in the kidney is leading to increased urinary dopamine excretion in young patients with essential hypertension.

本文言語English
ページ(範囲)29-39
ページ数11
ジャーナルClinical and Experimental Hypertension
16
1
DOI
出版ステータスPublished - 1994

ASJC Scopus subject areas

  • 内科学
  • 生理学

フィンガープリント

「Increased urinary dopamine excretion in Young patients with essential hypertension」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル