Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO

K. Adachi, Shinichi Takahashi, P. Melzer, K. L. Campos, T. Nelson, C. Kennedy, L. Sokoloff

研究成果: Article

58 引用 (Scopus)

抄録

Effects of inhibition of nitric oxide (NO) synthase by N(G)-nitro-L- arginine methyl ester (L-NAME) on the increases in local cerebral blood flow (LCBF) produced in the whisker-to-barrel sensory pathway by vibrissal stimulation were studied in conscious rats with the autoradiographic iodo[14C]antipyrine method. Unilateral whisker stroking increased LCBF in the ipsilateral trigeminal spinal and principal sensory nuclei, contralateral ventral posteromedial thalamic nucleus, and contralateral somatosensory barrel cortex. Intravenous L-NAME (30 mg/kg) lowered baseline LCBF without altering the percent increases due to stimulation. Intracisternal infusions of L-NAME in doses about 10 times the molar content of free arginine in brain inhibited brain NO synthase activity by 88%, but the percent augmentations of LCBF by stimulation remained unchanged. Chronic treatment with L-NAME (50 mg/kg ip twice daily for 4 days) inhibited NO synthase activity in brain by 84% but also failed to reduce the percent increases in LCBF due to stimulation. These results indicate that NO does not mediate the increases in LCBF associated with functional activation.

元の言語English
ジャーナルAmerican Journal of Physiology - Heart and Circulatory Physiology
267
発行部数6 36-6
出版物ステータスPublished - 1994
外部発表Yes

Fingerprint

Cerebrovascular Circulation
NG-Nitroarginine Methyl Ester
blood flow
nitric oxide
Nitric Oxide
Nitric Oxide Synthase
Vibrissae
nitric oxide synthase
arginine
Brain
antipyrine
Ventral Thalamic Nuclei
brain
Antipyrine
Somatosensory Cortex
Arginine
cortex
esters
rats
dosage

ASJC Scopus subject areas

  • Physiology
  • Agricultural and Biological Sciences(all)

これを引用

Adachi, K., Takahashi, S., Melzer, P., Campos, K. L., Nelson, T., Kennedy, C., & Sokoloff, L. (1994). Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. American Journal of Physiology - Heart and Circulatory Physiology, 267(6 36-6).

Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. / Adachi, K.; Takahashi, Shinichi; Melzer, P.; Campos, K. L.; Nelson, T.; Kennedy, C.; Sokoloff, L.

:: American Journal of Physiology - Heart and Circulatory Physiology, 巻 267, 番号 6 36-6, 1994.

研究成果: Article

Adachi, K, Takahashi, S, Melzer, P, Campos, KL, Nelson, T, Kennedy, C & Sokoloff, L 1994, 'Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO', American Journal of Physiology - Heart and Circulatory Physiology, 巻. 267, 番号 6 36-6.
Adachi, K. ; Takahashi, Shinichi ; Melzer, P. ; Campos, K. L. ; Nelson, T. ; Kennedy, C. ; Sokoloff, L. / Increases in local cerebral blood flow associated with somatosensory activation are not mediated by NO. :: American Journal of Physiology - Heart and Circulatory Physiology. 1994 ; 巻 267, 番号 6 36-6.
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