抄録
Effects of inhibition of nitric oxide (NO) synthase by N(G)-nitro-L- arginine methyl ester (L-NAME) on the increases in local cerebral blood flow (LCBF) produced in the whisker-to-barrel sensory pathway by vibrissal stimulation were studied in conscious rats with the autoradiographic iodo[14C]antipyrine method. Unilateral whisker stroking increased LCBF in the ipsilateral trigeminal spinal and principal sensory nuclei, contralateral ventral posteromedial thalamic nucleus, and contralateral somatosensory barrel cortex. Intravenous L-NAME (30 mg/kg) lowered baseline LCBF without altering the percent increases due to stimulation. Intracisternal infusions of L-NAME in doses about 10 times the molar content of free arginine in brain inhibited brain NO synthase activity by 88%, but the percent augmentations of LCBF by stimulation remained unchanged. Chronic treatment with L-NAME (50 mg/kg ip twice daily for 4 days) inhibited NO synthase activity in brain by 84% but also failed to reduce the percent increases in LCBF due to stimulation. These results indicate that NO does not mediate the increases in LCBF associated with functional activation.
本文言語 | English |
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ページ(範囲) | H2155-H2162 |
ジャーナル | American Journal of Physiology - Heart and Circulatory Physiology |
巻 | 267 |
号 | 6 36-6 |
DOI | |
出版ステータス | Published - 1994 |
ASJC Scopus subject areas
- 生理学
- 循環器および心血管医学
- 生理学(医学)