Independent antitumor spectrum of UCN-01 (7-hydroxystaurosporine) against gastric and colorectal cancers as detected by MTT assay

Sadanori Abe, Tetsuro Kubota, Yoshiro Saikawa, Yoshihide Otani, Toshiharu Furukawa, Masahiko Watanabe, Koichiro Kumai, Masaki Kitajima

研究成果: Article

抄録

To evaluate the clinical usefulness of 7-hydroxystaurosporine (UCN-01), we compared the antitumor spectrum of UCN-01 with those of conventional antitumor agents against 40 fresh gastric and 40 fresh colorectal cancer specimens using the MTT assay. At a cut-off concentration of 30 μg/ml, UCN-01 showed a higher efficacy rate than mitomycin C (MMC), cisplatin, and 5-fluorouracil (5-FU) against both gastric and colorectal cancers. With respect to the gastric cancer specimens, the antitumor spectrum of UCN-01 was independent from those of the other agents, while the patterns of antitumor effects of the conventional agents all correlated significantly with each other. For the colorectal cancer specimens, the pattern of UCN-01-sensitivity did not correlate with the patterns for 5-FU or MMC. In conclusion, UCN-01 may be useful for clinical application against gastric and colorectal cancer due to its different antitumor spectrum from conventionally available agents.

元の言語English
ページ(範囲)3605-3610
ページ数6
ジャーナルAnticancer Research
22
発行部数6 B
出版物ステータスPublished - 2002 11

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Stomach Neoplasms
Colorectal Neoplasms
Mitomycin
Fluorouracil
7-hydroxystaurosporine
Antineoplastic Agents
Cisplatin
Stomach

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

これを引用

Abe, S., Kubota, T., Saikawa, Y., Otani, Y., Furukawa, T., Watanabe, M., ... Kitajima, M. (2002). Independent antitumor spectrum of UCN-01 (7-hydroxystaurosporine) against gastric and colorectal cancers as detected by MTT assay. Anticancer Research, 22(6 B), 3605-3610.

Independent antitumor spectrum of UCN-01 (7-hydroxystaurosporine) against gastric and colorectal cancers as detected by MTT assay. / Abe, Sadanori; Kubota, Tetsuro; Saikawa, Yoshiro; Otani, Yoshihide; Furukawa, Toshiharu; Watanabe, Masahiko; Kumai, Koichiro; Kitajima, Masaki.

:: Anticancer Research, 巻 22, 番号 6 B, 11.2002, p. 3605-3610.

研究成果: Article

Abe, S, Kubota, T, Saikawa, Y, Otani, Y, Furukawa, T, Watanabe, M, Kumai, K & Kitajima, M 2002, 'Independent antitumor spectrum of UCN-01 (7-hydroxystaurosporine) against gastric and colorectal cancers as detected by MTT assay', Anticancer Research, 巻. 22, 番号 6 B, pp. 3605-3610.
Abe, Sadanori ; Kubota, Tetsuro ; Saikawa, Yoshiro ; Otani, Yoshihide ; Furukawa, Toshiharu ; Watanabe, Masahiko ; Kumai, Koichiro ; Kitajima, Masaki. / Independent antitumor spectrum of UCN-01 (7-hydroxystaurosporine) against gastric and colorectal cancers as detected by MTT assay. :: Anticancer Research. 2002 ; 巻 22, 番号 6 B. pp. 3605-3610.
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AU - Abe, Sadanori

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AU - Otani, Yoshihide

AU - Furukawa, Toshiharu

AU - Watanabe, Masahiko

AU - Kumai, Koichiro

AU - Kitajima, Masaki

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N2 - To evaluate the clinical usefulness of 7-hydroxystaurosporine (UCN-01), we compared the antitumor spectrum of UCN-01 with those of conventional antitumor agents against 40 fresh gastric and 40 fresh colorectal cancer specimens using the MTT assay. At a cut-off concentration of 30 μg/ml, UCN-01 showed a higher efficacy rate than mitomycin C (MMC), cisplatin, and 5-fluorouracil (5-FU) against both gastric and colorectal cancers. With respect to the gastric cancer specimens, the antitumor spectrum of UCN-01 was independent from those of the other agents, while the patterns of antitumor effects of the conventional agents all correlated significantly with each other. For the colorectal cancer specimens, the pattern of UCN-01-sensitivity did not correlate with the patterns for 5-FU or MMC. In conclusion, UCN-01 may be useful for clinical application against gastric and colorectal cancer due to its different antitumor spectrum from conventionally available agents.

AB - To evaluate the clinical usefulness of 7-hydroxystaurosporine (UCN-01), we compared the antitumor spectrum of UCN-01 with those of conventional antitumor agents against 40 fresh gastric and 40 fresh colorectal cancer specimens using the MTT assay. At a cut-off concentration of 30 μg/ml, UCN-01 showed a higher efficacy rate than mitomycin C (MMC), cisplatin, and 5-fluorouracil (5-FU) against both gastric and colorectal cancers. With respect to the gastric cancer specimens, the antitumor spectrum of UCN-01 was independent from those of the other agents, while the patterns of antitumor effects of the conventional agents all correlated significantly with each other. For the colorectal cancer specimens, the pattern of UCN-01-sensitivity did not correlate with the patterns for 5-FU or MMC. In conclusion, UCN-01 may be useful for clinical application against gastric and colorectal cancer due to its different antitumor spectrum from conventionally available agents.

KW - Colorectal cancer

KW - Gastric cancer

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