Indium lung disease

Kristin J. Cummings, Makiko Nakano, Kazuyuki Omae, Koichiro Takeuchi, Tatsuya Chonan, Yong Long Xiao, Russell A. Harley, Victor L. Roggli, Akira Hebisawa, Robert J. Tallaksen, Bruce C. Trapnell, Gregory A. Day, Rena Saito, Marcia L. Stanton, Eva Suarthana, Kathleen Kreiss

研究成果: Article査読

86 被引用数 (Scopus)

抄録

Background: Reports of pulmonary fibrosis, emphysema, and, more recently, pulmonary alveolar proteinosis (PAP) in indium workers suggested that workplace exposure to indium compounds caused several different lung diseases. Methods: To better understand the pathogenesis and natural history of indium lung disease, a detailed, systematic, multidisciplinary analysis of clinical, histopathologic, radiologic, and epidemiologic data for all reported cases and workplaces was undertaken. Results: Ten men (median age, 35 years) who produced, used, or reclaimed indium compounds were diagnosed with interstitial lung disease 4-13 years after first exposure (n = 7) or PAP 1-2 years after first exposure (n = 3). Common pulmonary histopathologic features in these patients included intraalveolar exudate typical of alveolar proteinosis (n = 9), cholesterol clefts and granulomas (n = 10), and fibrosis (n = 9). Two patients with interstitial lung disease had pneumothoraces. Lung disease progressed following cessation of exposure in most patients and was fatal in two. Radiographic data revealed that two patients with PAP subsequently developed fibrosis and one also developed emphysematous changes. Epidemiologic investigations demonstrated the potential for exposure to respirable particles and an excess of lung abnormalities among coworkers. Conclusions: Occupational exposure to indium compounds was associated with PAP, cholesterol ester crystals and granulomas, pulmonary fibrosis, emphysema, and pneumothoraces. The available evidence suggests exposure to indium compounds causes a novel lung disease that may begin with PAP and progress to include fibrosis and emphysema, and, in some cases, premature death. Prospective studies are needed to better define the natural history and prognosis of this emerging lung disease and identify effective prevention strategies.

本文言語English
ページ(範囲)1512-1521
ページ数10
ジャーナルChest
141
6
DOI
出版ステータスPublished - 2012 6

ASJC Scopus subject areas

  • 呼吸器内科
  • 集中医療医学
  • 循環器および心血管医学

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