Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α

Yasunori Okada, Hiroyuki Tsuchiya, Hirokazu Shimizu, Katsuro Tomita, Isao Nakanishi, Hiroshi Sato, Motoharu Seiki, Kyoko Yamashita, Taro Hayakawa

研究成果: Article査読

111 被引用数 (Scopus)

抄録

Production of a 92-kDa gelatinase / type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) was investigated with human sarcoma cell lines. Among the cytokines and growth factors examined, only human recombinant tumor necrosis factor α (TNFα) induced and stimulated the proteinase with concomitant increase in TIMP expression, but matrix metalloproteinase 2 (72-kDa gelatinase / type IV collagenase) expression was unchanged. These data suggest that gene expression of the two metalloproteinases is regulated in a different fashion and TNFα may be important to allow cancer cells to be more invasive and metastatic.

本文言語English
ページ(範囲)610-617
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
171
2
DOI
出版ステータスPublished - 1990 9月 14
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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