Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

Tetsuya Kawata; Hisao Ito; Ken Motoori; Takuya Ueda; Naoyuki Shigematsu; Yoshiya Furusawa; Marco Durante; Kerry George; Honglu Wu; Francis A. Cucinotta

doi:10.1269/jrr.43.s169

Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

Tetsuya Kawata, Hisao Ito, Ken Motoori, Takuya Ueda, Naoyuki Shigematsu, Yoshiya Furusawa, Marco Durante, Kerry George, Honglu Wu, Francis A. Cucinotta

研究成果: Article › 査読

7 被引用数 (Scopus)

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The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

本文言語	English
ページ（範囲）	S169-173
ジャーナル	Journal of radiation research
巻	43 Suppl
DOI	https://doi.org/10.1269/jrr.43.s169
出版ステータス	Published - 2002 12月
外部発表	はい

ASJC Scopus subject areas

放射線
放射線学、核医学およびイメージング
健康、毒物学および変異誘発

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10.1269/jrr.43.s169

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abstract = "The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.",

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T1 - Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

AU - Kawata, Tetsuya

AU - Ito, Hisao

AU - Motoori, Ken

AU - Ueda, Takuya

AU - Shigematsu, Naoyuki

AU - Furusawa, Yoshiya

AU - Durante, Marco

AU - George, Kerry

AU - Wu, Honglu

AU - Cucinotta, Francis A.

PY - 2002/12

Y1 - 2002/12

N2 - The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

AB - The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

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Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

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