Induction of chromosome damage by aniline and its C-hydroxylated metabolites in the root cells of Vicia faba

Nobuhiro Kanaya

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The induction of sister-chromatid exchanges (SCEs) and chromosome aberrations (CAs) by aniline hydrochloride (AH) and its C-hydroxylated metabolites, o-, m- and p-aminophenol, in the root cells of Vicia faba was examined. AH induced CAs, but not SCEs. AI1 the C-hydroxylated metabolites of aniline induced both SCEs and CAs. However, the treatment of cells with these metabolites at concentrations that did not cause significant increases in CAs resulted in significant increases in SCEs. These results seem to suggest that the substance that induced CAs in root cells treated with AH was not the C-hydroxylated metabolites of aniline.

本文言語English
ページ(範囲)311-315
ページ数5
ジャーナルMutation Research Letters
245
4
DOI
出版ステータスPublished - 1990 12

ASJC Scopus subject areas

  • 医学(全般)

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