Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov, Koji Atarashi, Nicolas Manel, Eoin L. Brodie, Tatsuichiro Shima, Ulas Karaoz, Dongguang Wei, Katherine C. Goldfarb, Clark A. Santee, Susan V. Lynch, Takeshi Tanoue, Akemi Imaoka, Kikuji Itoh, Kiyoshi Takeda, Yoshinori Umesaki, Kenya Honda, Dan R. Littman

研究成果: Article

2243 引用 (Scopus)

抄録

The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and antimicrobial defenses and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

元の言語English
ページ(範囲)485-498
ページ数14
ジャーナルCell
139
発行部数3
DOI
出版物ステータスPublished - 2009 10 30
外部発表Yes

Fingerprint

Th17 Cells
Bacteria
Citrobacter rodentium
Mucosal Immunity
Mammals
Interleukin-17
Immune system
Microbiota
Pathogens
Helper-Inducer T-Lymphocytes
Ileum
Microorganisms
Autoimmune Diseases
Small Intestine
Gastrointestinal Tract
Immune System
Mucous Membrane
Genes
Epithelial Cells
Inflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., ... Littman, D. R. (2009). Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. Cell, 139(3), 485-498. https://doi.org/10.1016/j.cell.2009.09.033

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. / Ivanov, Ivaylo I.; Atarashi, Koji; Manel, Nicolas; Brodie, Eoin L.; Shima, Tatsuichiro; Karaoz, Ulas; Wei, Dongguang; Goldfarb, Katherine C.; Santee, Clark A.; Lynch, Susan V.; Tanoue, Takeshi; Imaoka, Akemi; Itoh, Kikuji; Takeda, Kiyoshi; Umesaki, Yoshinori; Honda, Kenya; Littman, Dan R.

:: Cell, 巻 139, 番号 3, 30.10.2009, p. 485-498.

研究成果: Article

Ivanov, II, Atarashi, K, Manel, N, Brodie, EL, Shima, T, Karaoz, U, Wei, D, Goldfarb, KC, Santee, CA, Lynch, SV, Tanoue, T, Imaoka, A, Itoh, K, Takeda, K, Umesaki, Y, Honda, K & Littman, DR 2009, 'Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria', Cell, 巻. 139, 番号 3, pp. 485-498. https://doi.org/10.1016/j.cell.2009.09.033
Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U その他. Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. Cell. 2009 10 30;139(3):485-498. https://doi.org/10.1016/j.cell.2009.09.033
Ivanov, Ivaylo I. ; Atarashi, Koji ; Manel, Nicolas ; Brodie, Eoin L. ; Shima, Tatsuichiro ; Karaoz, Ulas ; Wei, Dongguang ; Goldfarb, Katherine C. ; Santee, Clark A. ; Lynch, Susan V. ; Tanoue, Takeshi ; Imaoka, Akemi ; Itoh, Kikuji ; Takeda, Kiyoshi ; Umesaki, Yoshinori ; Honda, Kenya ; Littman, Dan R. / Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. :: Cell. 2009 ; 巻 139, 番号 3. pp. 485-498.
@article{6c5f767559bc458696caad62996c52cd,
title = "Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria",
abstract = "The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and antimicrobial defenses and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.",
keywords = "CELLIMMUNO, HUMDISEASE, MICROBIO",
author = "Ivanov, {Ivaylo I.} and Koji Atarashi and Nicolas Manel and Brodie, {Eoin L.} and Tatsuichiro Shima and Ulas Karaoz and Dongguang Wei and Goldfarb, {Katherine C.} and Santee, {Clark A.} and Lynch, {Susan V.} and Takeshi Tanoue and Akemi Imaoka and Kikuji Itoh and Kiyoshi Takeda and Yoshinori Umesaki and Kenya Honda and Littman, {Dan R.}",
year = "2009",
month = "10",
day = "30",
doi = "10.1016/j.cell.2009.09.033",
language = "English",
volume = "139",
pages = "485--498",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

AU - Ivanov, Ivaylo I.

AU - Atarashi, Koji

AU - Manel, Nicolas

AU - Brodie, Eoin L.

AU - Shima, Tatsuichiro

AU - Karaoz, Ulas

AU - Wei, Dongguang

AU - Goldfarb, Katherine C.

AU - Santee, Clark A.

AU - Lynch, Susan V.

AU - Tanoue, Takeshi

AU - Imaoka, Akemi

AU - Itoh, Kikuji

AU - Takeda, Kiyoshi

AU - Umesaki, Yoshinori

AU - Honda, Kenya

AU - Littman, Dan R.

PY - 2009/10/30

Y1 - 2009/10/30

N2 - The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and antimicrobial defenses and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

AB - The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and antimicrobial defenses and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

KW - CELLIMMUNO

KW - HUMDISEASE

KW - MICROBIO

UR - http://www.scopus.com/inward/record.url?scp=70350343544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350343544&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2009.09.033

DO - 10.1016/j.cell.2009.09.033

M3 - Article

C2 - 19836068

AN - SCOPUS:70350343544

VL - 139

SP - 485

EP - 498

JO - Cell

JF - Cell

SN - 0092-8674

IS - 3

ER -