Induction of lamina propria Th17 cells by intestinal commensal bacteria

研究成果: Article査読

31 被引用数 (Scopus)

抄録

Th17 cells constitute a subset of activated CD4+ T cells, characterized by their production of interleukin (IL)-17, IL-17F, and IL-22, that play a critical role in host defence against extracellular pathogens. An intriguing feature of these cells is their selective and constitutive presence in the intestinal lamina propria. The development of intestinal Th17 cells is controlled by intestinal commensal bacteria. Recently, segmented filamentous bacterium (SFB) was identified as a specific bacterial taxon that promotes Th17 differentiation in the small intestine of mice. We discuss the recent advances in our understanding of the mechanism of intestinal Th17 synthesis and its potential implications for the treatment of inflammatory bowel diseases.

本文言語English
ページ(範囲)8036-8038
ページ数3
ジャーナルVaccine
28
50
DOI
出版ステータスPublished - 2010 11 23
外部発表はい

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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