抄録
Induction of the MexCD-OprJ multidrug efflux pump was investigated in wild-type Pseudomonas aeruginosa PAO1. MexCD-OprJ was induced by clinically important disinfectants such as benzalkonium chloride and chlorhexidine gluconate, and by some cytotoxic agents such as tetraphenylphosphonium chloride, ethidium bromide and rhodamine 6G. MexCD-OprJ was not induced by norfloxacin, tetracycline, chloramphenicol, streptomycin, erythromycin or carbenicillin, although they are substrates for the pump. Cells of PAO1 showed increased resistance to norfloxacin when grown in the presence of the inducers of the mexCD-oprJ operon mentioned above. These results indicate that MexCD-OprJ plays an important role in intrinsic multidrug resistance in wild-type P. aeruginosa in hospitals where disinfectants are used frequently.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 991-994 |
| ページ数 | 4 |
| ジャーナル | Journal of Antimicrobial Chemotherapy |
| 巻 | 51 |
| 号 | 4 |
| DOI | |
| 出版ステータス | Published - 2003 4月 1 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 薬理学
- 微生物学（医療）
- 感染症
- 薬理学（医学）
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
