Induction of neurite outgrowth of PC12 cells by an inhibitor of vacuolar H+-ATPase, bafilomycin A1

Hiro omi Tamura, Shoji Ohkuma

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Bafilomycin A1, a selective inhibitor of vacuolar H+-ATPase, induced neurite outgrowth of PC12 cells dose- and time-dependently: more than 50% of the cells extended neurite-like spikes after 24 h treatment with 100 nM bafilomycin A1. Its dose-response ran roughly parallel to that of a bafilomycin A1-induced lysosomal pH increase. It was inhibited by LiCl, an inhibitor of the phosphorylation of microtubule-associated proteins and, like nerve growth factor (NGF)-induced neurite outgrowth, it was also inhibited by cycloheximide and actinomycin D. But, unlike the NGF-effect, it was not associated with rapid induction of c-fos.

本文言語English
ページ(範囲)51-55
ページ数5
ジャーナルFEBS Letters
294
1-2
DOI
出版ステータスPublished - 1991 12月 2
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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