Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

Tomonori Hiramatsu, Masaya Imoto, Takashi Koyano, Kazuo Umezawa

研究成果: Article査読

85 被引用数 (Scopus)

抄録

We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The effect of damnacanthal was reversible, and the compound had no effect on the morphology of RSVts-NRK cells expressing the src oncogene. Thus, damnacanthal is a new inhibitor of ras function.

本文言語English
ページ(範囲)161-166
ページ数6
ジャーナルCancer Letters
73
2-3
DOI
出版ステータスPublished - 1993 9 30

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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