Inefficient phagosome maturation in infant macrophages

Fumiji Saito, Hirotaka Kuwata, Eiji Oiki, Masato Koike, Yasuo Uchiyama, Kenya Honda, Kiyoshi Takeda

研究成果: Article査読

10 被引用数 (Scopus)

抄録

The quantitative and qualitative differences between the immune systems of infants and adults have been extensively investigated in the context of adaptive immunity. Here, we demonstrate that the infantile innate immune system is immature and weak against bacterial infections. Upon infection by Escherichia coli, macrophages from infantile mice showed a lower performance in killing the bacteria. In infant macrophages, bacteria were taken up relatively normally and delivered into lysosomal compartments, but not efficiently digested. The inefficient bacterial killing in infant macrophages was correlated with impaired acidification of the lysosomal compartments and reduced lysosomal recruitment of Rab7, an essential component of the acidification process. The acidification defect was not intrinsic to the cells, and was rescued by pretreatment with interferon-γ. Thus, we propose that the limited capacity of phagosome maturation is one of the major causes of the high sensitivity to infectious microorganisms during infancy and that the specific cytokine milieu shapes the nature of infantile innate immunity.

本文言語English
ページ(範囲)113-118
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
375
1
DOI
出版ステータスPublished - 2008 10 10
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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