Inexplicable suppression of hepatic uptake of gallium-67, a case report

Tadaki Nakahara, H. Fujii, K. Nakamura, J. Hashimoto, A. Kubo

研究成果: Article

抄録

We describe here a case report of a patient with acute lymphocytic leukemia in whom hepatic gallium-67 (Ga-67) uptake was suppressed. The patient was hospitalized with increasing dyspnea. In Ga-67 scintigraphy, there was no hepatic uptake, although other physiological uptake was clearly observed. In addition, the scintigraphy showed increased accumulation in the right lung consistent with infection. We considered possible reasons for these findings. The patient had no history of chemotherapy or blood transfusion, and his iron metabolism was almost normal. He was not receiving any medication which might reduce hepatic blood flow. Blood chemistry suggested normal hepatic and renal function. The patient died from pneumonia 6 weeks later. The autopsy revealed extensive infiltration of the right lung with Bacillus cereus (B. cereus). Metabolic acidosis and/or iron utilization of B. cereus may induce both increased Ga-67 accumulation in the infected lesion and suppressed uptake in the liver, but these mechanisms could not explain normal physiological uptake in the other organs. This case warranted the further study of the hepatic Ga67 uptake mechanism.

元の言語English
ページ(範囲)377-379
ページ数3
ジャーナルAnnals of Nuclear Medicine
15
発行部数4
出版物ステータスPublished - 2001

Fingerprint

Gallium
Liver
Bacillus cereus
Radionuclide Imaging
Iron
Lung
Acidosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Blood Transfusion
Dyspnea
Autopsy
Pneumonia
Kidney
Drug Therapy
Infection

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

これを引用

Nakahara, T., Fujii, H., Nakamura, K., Hashimoto, J., & Kubo, A. (2001). Inexplicable suppression of hepatic uptake of gallium-67, a case report. Annals of Nuclear Medicine, 15(4), 377-379.

Inexplicable suppression of hepatic uptake of gallium-67, a case report. / Nakahara, Tadaki; Fujii, H.; Nakamura, K.; Hashimoto, J.; Kubo, A.

:: Annals of Nuclear Medicine, 巻 15, 番号 4, 2001, p. 377-379.

研究成果: Article

Nakahara, T, Fujii, H, Nakamura, K, Hashimoto, J & Kubo, A 2001, 'Inexplicable suppression of hepatic uptake of gallium-67, a case report', Annals of Nuclear Medicine, 巻. 15, 番号 4, pp. 377-379.
Nakahara, Tadaki ; Fujii, H. ; Nakamura, K. ; Hashimoto, J. ; Kubo, A. / Inexplicable suppression of hepatic uptake of gallium-67, a case report. :: Annals of Nuclear Medicine. 2001 ; 巻 15, 番号 4. pp. 377-379.
@article{7855085951ec4fb9bf2145f0023fc8b2,
title = "Inexplicable suppression of hepatic uptake of gallium-67, a case report",
abstract = "We describe here a case report of a patient with acute lymphocytic leukemia in whom hepatic gallium-67 (Ga-67) uptake was suppressed. The patient was hospitalized with increasing dyspnea. In Ga-67 scintigraphy, there was no hepatic uptake, although other physiological uptake was clearly observed. In addition, the scintigraphy showed increased accumulation in the right lung consistent with infection. We considered possible reasons for these findings. The patient had no history of chemotherapy or blood transfusion, and his iron metabolism was almost normal. He was not receiving any medication which might reduce hepatic blood flow. Blood chemistry suggested normal hepatic and renal function. The patient died from pneumonia 6 weeks later. The autopsy revealed extensive infiltration of the right lung with Bacillus cereus (B. cereus). Metabolic acidosis and/or iron utilization of B. cereus may induce both increased Ga-67 accumulation in the infected lesion and suppressed uptake in the liver, but these mechanisms could not explain normal physiological uptake in the other organs. This case warranted the further study of the hepatic Ga67 uptake mechanism.",
keywords = "Gallium-67 scintigraphy, Hepatic uptake, Physiological uptake",
author = "Tadaki Nakahara and H. Fujii and K. Nakamura and J. Hashimoto and A. Kubo",
year = "2001",
language = "English",
volume = "15",
pages = "377--379",
journal = "Annals of Nuclear Medicine",
issn = "0914-7187",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Inexplicable suppression of hepatic uptake of gallium-67, a case report

AU - Nakahara, Tadaki

AU - Fujii, H.

AU - Nakamura, K.

AU - Hashimoto, J.

AU - Kubo, A.

PY - 2001

Y1 - 2001

N2 - We describe here a case report of a patient with acute lymphocytic leukemia in whom hepatic gallium-67 (Ga-67) uptake was suppressed. The patient was hospitalized with increasing dyspnea. In Ga-67 scintigraphy, there was no hepatic uptake, although other physiological uptake was clearly observed. In addition, the scintigraphy showed increased accumulation in the right lung consistent with infection. We considered possible reasons for these findings. The patient had no history of chemotherapy or blood transfusion, and his iron metabolism was almost normal. He was not receiving any medication which might reduce hepatic blood flow. Blood chemistry suggested normal hepatic and renal function. The patient died from pneumonia 6 weeks later. The autopsy revealed extensive infiltration of the right lung with Bacillus cereus (B. cereus). Metabolic acidosis and/or iron utilization of B. cereus may induce both increased Ga-67 accumulation in the infected lesion and suppressed uptake in the liver, but these mechanisms could not explain normal physiological uptake in the other organs. This case warranted the further study of the hepatic Ga67 uptake mechanism.

AB - We describe here a case report of a patient with acute lymphocytic leukemia in whom hepatic gallium-67 (Ga-67) uptake was suppressed. The patient was hospitalized with increasing dyspnea. In Ga-67 scintigraphy, there was no hepatic uptake, although other physiological uptake was clearly observed. In addition, the scintigraphy showed increased accumulation in the right lung consistent with infection. We considered possible reasons for these findings. The patient had no history of chemotherapy or blood transfusion, and his iron metabolism was almost normal. He was not receiving any medication which might reduce hepatic blood flow. Blood chemistry suggested normal hepatic and renal function. The patient died from pneumonia 6 weeks later. The autopsy revealed extensive infiltration of the right lung with Bacillus cereus (B. cereus). Metabolic acidosis and/or iron utilization of B. cereus may induce both increased Ga-67 accumulation in the infected lesion and suppressed uptake in the liver, but these mechanisms could not explain normal physiological uptake in the other organs. This case warranted the further study of the hepatic Ga67 uptake mechanism.

KW - Gallium-67 scintigraphy

KW - Hepatic uptake

KW - Physiological uptake

UR - http://www.scopus.com/inward/record.url?scp=0034794759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034794759&partnerID=8YFLogxK

M3 - Article

C2 - 11577765

AN - SCOPUS:0034794759

VL - 15

SP - 377

EP - 379

JO - Annals of Nuclear Medicine

JF - Annals of Nuclear Medicine

SN - 0914-7187

IS - 4

ER -