[Inflammatory bowel disease and colorectal cancer].

Tadakazu Hisamatsu

研究成果: Review article査読

2 被引用数 (Scopus)

抄録

Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD), have been considered as a risk of colorectal cancer (CRC). CRC associated with chronic intestinal inflammation has been known as "colitic cancer". Molecular mechanisms for developing of colitic cancer are different from those of sporadic CRC known as adenomacarcinoma sequence. Colitic cancer often involves dysplasia as precancerous lesions. Mutation of p53 gene is often observed not only in colitic cancer but also in dysplasia. Theory of "field cancerization" applies in colitic cancer resulting in several difficulties in clinical management of it such as multifocality and heterochrony.

本文言語English
ページ(範囲)56-62
ページ数7
ジャーナルUnknown Journal
72
1
出版ステータスPublished - 2014 1

ASJC Scopus subject areas

  • 医学(全般)

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