We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.
|ジャーナル||Japanese Journal of Chemotherapy|
|出版ステータス||Published - 2004 10|
ASJC Scopus subject areas
- Pharmacology (medical)