TY - JOUR
T1 - Influence of antimicrobial drugs on free bilirubin concentration in neonates
AU - Sando, M.
AU - Sato, Y.
AU - Iwata, S.
AU - Akita, H.
AU - Sunakawa, K.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/10
Y1 - 2004/10
N2 - We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.
AB - We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.
KW - Antimicrobial agent
KW - Neonate
KW - Serum bilirubin
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M3 - Article
AN - SCOPUS:8844274872
VL - 52
SP - 574
EP - 582
JO - Japanese Journal of Chemotherapy
JF - Japanese Journal of Chemotherapy
SN - 1340-7007
IS - 10
ER -