Influence of biochemical composition on dynamic visco-elastic property of chondrocyte/agarose construct

Shogo Miyata, Katsuko Furukawa, Takashi Ushida, Tetsuya Tateishi

研究成果: Conference contribution

1 被引用数 (Scopus)

抄録

Recently, an approach to restore cartilage defects, culturing autologous chondrocytes to create a three dimensional tissue, has been developed. In this kind of approach, it is important to study whether the extracellular matrices synthesized by cultured chondrocytes have dynamic mechanical properties unique to articular cartilage. In this study, we evaluated in detail dynamic visco-elastic properties of chondrocyte/agarose constructs in compression and shear directions, and compared those properties with biochemical composition. As the results, the dynamic modulus of the constructs increased over the culture time. Furthermore, a regression analysis showed that the sulfated glycosaminoglycan (sGAG) content is correlated strongly with dynamic stiffness in both compression and shear deformation. On the other hand, loss tangent, which represents an energy dissipation capability of the constructs, showed little correlation with sGAG content.

本文言語English
ホスト出版物のタイトルProceedings of the 3rd IASTED International Conference on Biomedical Engineering 2005
編集者M.H. Hamza
ページ515-518
ページ数4
出版ステータスPublished - 2005
外部発表はい
イベント3rd IASTED International Conference on Medical Engineering 2005 - Innsbruck, Austria
継続期間: 2005 2 162005 2 18

出版物シリーズ

名前Proceedings of the 3rd IASTED International Conference on Biomedical Engineering 2005

Other

Other3rd IASTED International Conference on Medical Engineering 2005
国/地域Austria
CityInnsbruck
Period05/2/1605/2/18

ASJC Scopus subject areas

  • 工学(全般)

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