Influence of calmodulin antagonists on Ca2+transport in the lens

Atsushi Iimuro, Makoto Takehana, Shuzo Iwata

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Attempts were made to elucidate the relation between lens opacification resulting from inhibition of Ca2+transport and high calcium accumulation in the lens. Mouse lenses were incubated with naphthalenesulfonamide compounds (W-5, W-7, W-12 and W-13) which act as calmodulin antagonists. When lens Ca2+-ATPase activity was inhibited by those calmodulin antagonists, an accumulation of calcium in the lens was observed. This phenomenon depended on the chemical structure of calmodulin antagonist. In lenses treated with W-7, more than 97% of excess calcium was bound. Insoluble protein increased from 8.5 to 17% of the total protein and the degree of lens opacification increased to 85.1%. These results suggested that dysfunction of the Ca-pump system leads to calcium accumulation, thus in turn inducing protein dénaturation which in turn is followed by lens opacification.

本文言語English
ページ(範囲)95-100
ページ数6
ジャーナルOphthalmic research
19
2
DOI
出版ステータスPublished - 1987 1月 1

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

フィンガープリント

「Influence of calmodulin antagonists on Ca2+transport in the lens」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル