Influence of mRNA and protein synthesis inhibitors on the long-term memory acquisition of classically conditioned earthworms

Hikaru Watanabe, Tomohiro Takaya, Toshinobu Shimoi, Hiroto Ogawa, Yoshiichiro Kitamura, Kotaro Oka

研究成果: Article査読

20 被引用数 (Scopus)

抄録

We investigated the process of memory consolidation following classical conditioning of earthworms. Earthworms were conditioned in paired trials by a weak vibration as a conditioned stimulus (CS), and by light as an unconditioned stimulus (US). The occurrence of a shrinking response upon exposure to the CS increased steadily with the number of paired training trials. When the training procedure was changed by increasing the intertrial interval (ITI), it was found that only those worms trained with a 68 s ITI exhibited long-term memory retention for at least 24 h. The influence of mRNA synthesis inhibition by actinomycin-D or of protein synthesis by anisomycin on memory consolidation was also examined. Induction of the long-term memory was blocked when either of these two compounds was injected into the body cavity of the worm within 25 min of conditioning with the 68 s ITI. These results demonstrate that the long-term memory is dependent upon protein synthesis in response to the upregulation of new transcription messengers.

本文言語English
ページ(範囲)151-157
ページ数7
ジャーナルNeurobiology of Learning and Memory
83
2
DOI
出版ステータスPublished - 2005 3

ASJC Scopus subject areas

  • 実験心理学および認知心理学
  • 認知神経科学
  • 行動神経科学

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