抄録
A cell adhesive peptide, Arg-Gly-Asp-Ser (RGDS), enhances leucocyte response to stimuli when insolubilized or conjugated with proteins. In order to investigate the contribution of the microsphere structure to leucocyte response, RGDS was immobilized onto several polymeric microspheres. The respiratory burst of polymorphonuclear leucocytes (PMNs) contacting microspheres was enhanced by RGDS in cases where it was immobilized on polystyrene and, more effectively, a positively charged one. This was not observed in polyacrylamide-based or negative-charged microsphere systems. These results demonstrate that the property of supports strongly affects the regulation of the PMN response via an adhesive interaction.
本文言語 | English |
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ページ(範囲) | 570-576 |
ページ数 | 7 |
ジャーナル | Biomaterials |
巻 | 15 |
号 | 8 |
DOI | |
出版ステータス | Published - 1994 6月 |
ASJC Scopus subject areas
- バイオエンジニアリング
- セラミックおよび複合材料
- 生物理学
- 生体材料
- 材料力学