Influence of the structure of support microspheres on leucocyte activation by RGDS-carrying microspheres

Yuji Kasuya, Keiji Fujimoto, Haruma Kawaguchi, Masaki Miyamoto

研究成果: Article査読

6 被引用数 (Scopus)

抄録

A cell adhesive peptide, Arg-Gly-Asp-Ser (RGDS), enhances leucocyte response to stimuli when insolubilized or conjugated with proteins. In order to investigate the contribution of the microsphere structure to leucocyte response, RGDS was immobilized onto several polymeric microspheres. The respiratory burst of polymorphonuclear leucocytes (PMNs) contacting microspheres was enhanced by RGDS in cases where it was immobilized on polystyrene and, more effectively, a positively charged one. This was not observed in polyacrylamide-based or negative-charged microsphere systems. These results demonstrate that the property of supports strongly affects the regulation of the PMN response via an adhesive interaction.

本文言語English
ページ(範囲)570-576
ページ数7
ジャーナルBiomaterials
15
8
DOI
出版ステータスPublished - 1994 6月

ASJC Scopus subject areas

  • バイオエンジニアリング
  • セラミックおよび複合材料
  • 生物理学
  • 生体材料
  • 材料力学

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