Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung

T. Yano, H. Yokoyama, Y. Fukuyama, E. Takaai, Y. Tanaka, J. Miyagi, S. Kuninaka, H. Asoh, Y. Ichinose

研究成果: Article査読

抄録

In order to inhibit an airborne metastasis of bronchiolo alveolar cell carcinoma, we tried to activate alveolar macrophages by inhalation of aerosolized OK-432 (streptococcal preparation). When the alveolar macrophages obtained from resected specimens from lung cancer patients were cultured for 24 h in the presence of various concentrations of OK-432 (0.001, 0.01, 0.1 1 KE/ml), the cytotoxic activity against a lung cancer cell line, QG 56, was augmented in a dose dependent manner. After 72 h cultivation with 0.1 KE/ml of OK-432, the alveolar macrophages produced various cytokines, ie, IL-1, TNF-α, and IL-6. Based on the in vitro experiments, three patients with intrapulmonary metastatic bronchiolo alveolar carcinoma were treated by inhalation of aerosolized OK-432 (0.1 KE/ml). The inhalation therapy was safe without any adverse effects and resulted in both the augmentation of antitumor cytotoxicity and the induction of TNF-α production by the alveolar macrophages.

本文言語English
ページ(範囲)321-323
ページ数3
ジャーナルBiotherapy
11
3
出版ステータスPublished - 1997 1 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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