抄録
Cultured human umbilical vein endothelial cells inhibited the platelet aggregating activity of thrombin in the absence of plasma. Using a new method in which thrombin-induced platelet aggregation was measured in the presence of endothelial cells, we showed that aspirin-treated endothelial cells inhibited platelet aggregating activity of thrombin in an incubation time- and cell number-dependent manner. This inhibitory effect of endothelial cells was partially blocked by the pretreatment of endothelial cells with monoclonal anti-thrombomodulin IgG(anti-TMIgG). It is suggested that (1) endothelial cells play a role in the clearance of thrombin by binding and inactivating this enzyme and that (2) thrombomodulin on endothelial cells, apart from its role for protein C activation, may be involved in this endothelial function.
本文言語 | English |
---|---|
ページ(範囲) | 647-656 |
ページ数 | 10 |
ジャーナル | Thrombosis Research |
巻 | 50 |
号 | 5 |
DOI | |
出版ステータス | Published - 1988 6月 1 |
ASJC Scopus subject areas
- 血液学