Inhibition of 12-0-Tetradecanoylphorbol43-Acetate-Induced Tumor Promotion and Epidermal Ornithine Decarboxylase Activity in Mouse Skin by Palmitoylcarnitine

Teruo Nakadate, Satoshi Yamamoto, Eriko Aizu, Ryuichi Kato

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Palmitoylcarnitine, which has been reported to be an inhibitor of calcium-activated, phospholipid-dependent protein kinase (protein kinase C), inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal ornithine decarboxylase in mouse skin in a dose-dependent manner. Neither acetylcarnitine nor palmitk acid inhibited TPA-caused ornithine decarboxyhtse induction. in addition, palmitoylcarnitine markedly inhibited skin tumor promotion induced by TPA. Palmitoylcarnitine inhibited epidermal protein kinase C activity which was stimulated by Ca2+ in the presence of phosphatidylserine but failed to inhibit the enzyme activity which was stimulated by TPA in the presence of either phosphatidylserine or Ca2+plus phosphatidylserine. Therefore, it seems unlikely that the potent anti-tumor-promoting action of palmitoylatrnitine which is shown in the present study, is explained solely by its effect on protein kinase C.

本文言語English
ページ(範囲)1589-1593
ページ数5
ジャーナルCancer Research
46
出版ステータスPublished - 1986 4

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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「Inhibition of 12-0-Tetradecanoylphorbol43-Acetate-Induced Tumor Promotion and Epidermal Ornithine Decarboxylase Activity in Mouse Skin by Palmitoylcarnitine」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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