Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H+-ATPase

Shoji Ohkuma, Sakae Shimizu, Masahiko Noto, Yoshimichi Sai, Kuninori Kinoshita, Hiro Omi Tamura

研究成果: Article査読

44 被引用数 (Scopus)

抄録

Bafilomycin A1, a potent selective inhibitor of vacuolar H+-ATPase, inhibited the growth of a variety of cultured cells dose-dependently, including golden hamster embryo and NIH-3T3 fibroblasts, whether or not they were transformed, and PC12 and HeLa cells. The concentration of bafilomycin A1 for 50% inhibition of cell growth ranged from 10 to 50 n M. The dose response was nearly parallel with that of the bafilomycin A1-induced lysosomal pH increase. The degree of pH increase for growth inhibition produced by bafilomycin A1 was similar to that produced by NH4Cl in which little difference was recognized in effect among cell types.

本文言語English
ページ(範囲)862-866
ページ数5
ジャーナルIn Vitro Cellular & Developmental Biology - Animal: Journal of the Society for In Vitro Biology
29
11
DOI
出版ステータスPublished - 1993 11月
外部発表はい

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学

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