Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin

Masaya Imoto, Takashi Yamashita, Tsutomu Sawa, Shogo Kurasawa, Hiroshi Naganawa, Tomio Takeuchi, Z. Bao-quan, Kazuo Umezawa

研究成果: Article査読

52 被引用数 (Scopus)

抄録

Psi-tectorigenin, an isoflavonoid, was isolated from a culture filtrate of actinomycetes as an inhibitor of epidermal growth factor-induced phosphatidylinositol turnover in cultured A431 cells. It inhibited phosphatidylinositol turnover with an IC50 of about 1 μg/ml; thus, its inhibitory activity was 6-times stronger than that of genistein or orobol. When added to cultured A431 cells psi-tectorigenin inhibited phosphatidylinositol turnover without inhibiting epidermal growth factor receptor tyrosine protein kinase. Thus, psi-tectorigenin is a specific inhibitor of phosphatidylinositol turnover and may be a useful tool for the functional analysis of phosphatidylinositol turnover.

本文言語English
ページ(範囲)43-46
ページ数4
ジャーナルFEBS Letters
230
1-2
DOI
出版ステータスPublished - 1988 3月 28
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

フィンガープリント

「Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル