抄録
Vitamin C is mainly transported across the blood-retinal and -brain barriers as dehydroascorbic acid (DHA) via a facilitative glucose transporter, GLUT1, and accumulates as ascorbic acid in the retina and brain. To investigate whether DHA transport to the retina and brain is changed by hyperglycemia, [14C]DHA transport across the blood-retinal and -brain barriers was examined using in vivo integration plot analysis in streptozotocin-induced diabetic rats with a 3-week duration of diabetes and in normal rats. Blood-to-retina and -brain transport of [14C]DHA was reduced by 65.5% and 84.1%, respectively, in diabetic rats compared with normal rats, whereas there was no major difference in the heart. Therefore, we propose that hyperglycemia reduces the supply of vitamin C to the retina and brain.
本文言語 | English |
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ページ(範囲) | 2148-2150 |
ページ数 | 3 |
ジャーナル | Biological and Pharmaceutical Bulletin |
巻 | 29 |
号 | 10 |
DOI | |
出版ステータス | Published - 2006 |
外部発表 | はい |
ASJC Scopus subject areas
- 薬理学
- 薬科学