Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism

Tadahiko Mashino, Kensuke Okuda, Takashi Hirota, Masaaki Hirobe, Tetsuo Nagano, Masataka Mochizuki

研究成果: Article

87 引用 (Scopus)

抜粋

Cationic ammonium fullerene derivatives (C60-bis(N,N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.

元の言語English
ページ(範囲)2959-2962
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
9
発行部数20
DOI
出版物ステータスPublished - 1999 10 18

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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