Inhibition of enteropeptidase by antitrypsin drugs

Masashi Matsushima, Naohisa Yahagi, Masao Ichinose, Kazumasa Miki, Masao Omata, Hideshi Inoue, Takayuki Takahashi, Kenji Takahashi

研究成果: Article

抄録

We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.

元の言語English
ページ(範囲)257-260
ページ数4
ジャーナルBiomedical Research
22
発行部数5
出版物ステータスPublished - 2001
外部発表Yes

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Enteropeptidase
Trypsin
Pharmaceutical Preparations
Trypsin Inhibitors
Inhibitory Concentration 50
Swine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Matsushima, M., Yahagi, N., Ichinose, M., Miki, K., Omata, M., Inoue, H., ... Takahashi, K. (2001). Inhibition of enteropeptidase by antitrypsin drugs. Biomedical Research, 22(5), 257-260.

Inhibition of enteropeptidase by antitrypsin drugs. / Matsushima, Masashi; Yahagi, Naohisa; Ichinose, Masao; Miki, Kazumasa; Omata, Masao; Inoue, Hideshi; Takahashi, Takayuki; Takahashi, Kenji.

:: Biomedical Research, 巻 22, 番号 5, 2001, p. 257-260.

研究成果: Article

Matsushima, M, Yahagi, N, Ichinose, M, Miki, K, Omata, M, Inoue, H, Takahashi, T & Takahashi, K 2001, 'Inhibition of enteropeptidase by antitrypsin drugs', Biomedical Research, 巻. 22, 番号 5, pp. 257-260.
Matsushima M, Yahagi N, Ichinose M, Miki K, Omata M, Inoue H その他. Inhibition of enteropeptidase by antitrypsin drugs. Biomedical Research. 2001;22(5):257-260.
Matsushima, Masashi ; Yahagi, Naohisa ; Ichinose, Masao ; Miki, Kazumasa ; Omata, Masao ; Inoue, Hideshi ; Takahashi, Takayuki ; Takahashi, Kenji. / Inhibition of enteropeptidase by antitrypsin drugs. :: Biomedical Research. 2001 ; 巻 22, 番号 5. pp. 257-260.
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