Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors

Kazuo Umezawa, Takashi Hori, Hirohisa Tajima, Masaya Imoto, Kunio Isshiki, Tomio Takeuchi

研究成果: Article査読

12 被引用数 (Scopus)

抄録

We prepared methyl 2,5-dihydroxycinnamate as a stable analogue of erbstatin, a tyrosine kinase inhibitor. This analogue was about 4 times more stable than erbstatin in calf serum. It inhibited epidermal growth factor receptor-associated tyrosine kinase in vitro with an IC50 of 0.15 μg ml. It also inhibited in situ autophosphorylation of epidermal growth factor receptor in A431 cells. Methyl 2,5-dihydroxycinnamate was shown to delay the S-phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount ofDNA synthesis. The effect of erbstatin on S-phase induction was smaller, possibly because of its shorter life time.

本文言語English
ページ(範囲)198-200
ページ数3
ジャーナルFEBS Letters
260
2
DOI
出版ステータスPublished - 1990 1月 29
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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