Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide

Takuhiro Sonoyama, Naohisa Tamura, Kazutoshi Miyashita, Kwijun Park, Naofumi Oyamada, Daisuke Taura, Megumi Inuzuka, Yasutomo Fukunaga, Masakatsu Sone, Kazuwa Nakao

研究成果: Article

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Anti-fibrotic and organ protective effects of brain natriuretic peptide (BNP) have been reported. In this study, effects of BNP on liver fibrosis were examined in the carbon tetrachloride (CCl4)-induced liver fibrosis model using BNP-transgenic (Tg) and wild-type (WT) mice. Twice-a-week intraperitoneal injections of CCl4 for 8 weeks resulted in massive liver fibrosis, augmented transforming growth factor (TGF)-β1 and type I procollagen α1 chain (Col1a1) mRNA expression, and the hepatic stellate cell (HSC) activation in WT mice, all of which were significantly suppressed in Tg mice. These observations indicate that BNP inhibits liver fibrosis by attenuating the activation of HSCs.

元の言語English
ページ(範囲)2067-2070
ページ数4
ジャーナルFEBS Letters
583
発行部数12
DOI
出版物ステータスPublished - 2009 6 18

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Sonoyama, T., Tamura, N., Miyashita, K., Park, K., Oyamada, N., Taura, D., Inuzuka, M., Fukunaga, Y., Sone, M., & Nakao, K. (2009). Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide. FEBS Letters, 583(12), 2067-2070. https://doi.org/10.1016/j.febslet.2009.05.025