Inhibition of human immunodeficiency virus type 1 (HIV-1) nuclear import via Vpr-Importin α interactions as a novel HIV-1 therapy

Tatsunori Suzuki, Norio Yamamoto, Mizuho Nonaka, Yoshie Hashimoto, Go Matsuda, Shin nosuke Takeshima, Megumi Matsuyama, Tatsuhiko Igarashi, Tomoyuki Miura, Rie Tanaka, Shingo Kato, Yoko Aida

研究成果: Article査読

29 被引用数 (Scopus)

抄録

The development of multidrug-resistant viruses compromises the efficacy of anti-human immunodeficiency virus (HIV) therapy and limits treatment options. Therefore, new targets that can be used to develop novel antiviral agents need to be identified. One such target is the interaction between Vpr, one of the accessory gene products of HIV-1 and Importin α, which is crucial, not only for the nuclear import of Vpr, but also for HIV-1 replication in macrophages. We have identified a potential parent compound, hematoxylin, which suppresses Vpr-Importin α interaction, thereby inhibiting HIV-1 replication in a Vpr-dependent manner. Analysis by real-time PCR demonstrated that hematoxylin specifically inhibited nuclear import step of pre-integration complex. Thus, hematoxylin is a new anti-HIV-1 inhibitor that targets the nuclear import of HIV-1 via the Vpr-Importin α interaction, suggesting that a specific inhibitor of the interaction between viral protein and the cellular factor may provide a new strategy for HIV-1 therapy.

本文言語English
ページ(範囲)838-843
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
380
4
DOI
出版ステータスPublished - 2009 3 20

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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