Inhibition of microtubule polymerization by synthetic estrogens: Formation of a ribbon structure

Yoshihiro Sato, Tomoko Murai, Taiko Oda, Hazime Saitô, Masahiko Kodama, Aiko Hirata

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Dienestrol, meso-hexestrol, and dl-hexestrol, synthetic nonsteroidal estrogens, were shown to be inhibitors of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The order of activity of the synthetic estrogens as inhibitors of microtubule assembly is: dienestrol>diethylstilbestrol<meso-hex-estrol>dl-hexestrol>isodienestrol. The activity of dienestrol as an inhibitor was of the same order as that of (+)-griseofulvin, as determined by turbidity measurement. Electron microscopic observation revealed that twisted ribbon structures are formed from microtubule proteins in the presence of some synthetic estrogens (dienestrol, meso-hexestrol, and dl-hexestrol).

本文言語English
ページ(範囲)1247-1252
ページ数6
ジャーナルJournal of biochemistry
101
5
DOI
出版ステータスPublished - 1987

ASJC Scopus subject areas

  • 生化学
  • 分子生物学

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