TY - JOUR
T1 - Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin
AU - Tamura, Hiro omi
AU - Noto, Masahiko
AU - Kinoshita, Kuninori
AU - Ohkuma, Shoji
AU - Ikezawa, Hiroh
N1 - Funding Information:
Acknowledgements-We are grateful to Dr K. HAYASHI for his generous gift of mouse 7S NGF. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Ctillture of Japan.
PY - 1994/5
Y1 - 1994/5
N2 - H-o. Tamura, M. Noto, K. Kinoshita, S. Ohkuma and H. Ikezawa. Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin. Toxicon 32, 629-633, 1994.-Sphingomyelinase of Bacillus cereus, a bacterial hemolysin, reduced nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells in a dose-dependent manner. At 200 mU/ml, sphingomyelinase repressed half the neurite outgrowth of the cells at 250 ng/ml NGF. The c-fos superinduction, one of the early responses induced by NGF, was not influenced by this treatment, suggesting that the repression by sphingomyelinase occurred via a protein kinase C-independent pathway.
AB - H-o. Tamura, M. Noto, K. Kinoshita, S. Ohkuma and H. Ikezawa. Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin. Toxicon 32, 629-633, 1994.-Sphingomyelinase of Bacillus cereus, a bacterial hemolysin, reduced nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells in a dose-dependent manner. At 200 mU/ml, sphingomyelinase repressed half the neurite outgrowth of the cells at 250 ng/ml NGF. The c-fos superinduction, one of the early responses induced by NGF, was not influenced by this treatment, suggesting that the repression by sphingomyelinase occurred via a protein kinase C-independent pathway.
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U2 - 10.1016/0041-0101(94)90211-9
DO - 10.1016/0041-0101(94)90211-9
M3 - Article
C2 - 8079375
AN - SCOPUS:0028337151
VL - 32
SP - 629
EP - 633
JO - Toxicon
JF - Toxicon
SN - 0041-0101
IS - 5
ER -