Inhibition of phosphatidylinositol-specific phospholipase C activity by Fluvirucin B2

H. Ul, Masaya Imoto, K. Umizawa

研究成果: Article

17 引用 (Scopus)

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We isolated fluvirucin B, from the culture broth of Streptomyces as an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). It inhibited PI-PLC of A431 cell cytosol with an IC50 of 1.6 μg/ml. Fluvirucin B2 also inhibited PI-PLC in cultured A431 cells, whereas it did not inhibit phosphatidylinositol synthesis and macromolecular synthesis markedly. It also inhibited epidermal growth factor-induced rapid rounding of A431 cells, in which PI turnover is involved.

元の言語English
ページ(範囲)387-390
ページ数4
ジャーナルJournal of Antibiotics
48
発行部数5
出版物ステータスPublished - 1995

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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