Inhibition of Phosphatidylinositol-specific Phospholipase C Activity by Fluvirucin B2

Hideaki Ui, Masaya Imoto, Kazuo Umezawa

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We isolated fluvirucin B2from the culture broth of Streptomyces as an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). It inhibited PI-PLC of A431 cell cytosol with an IC50 of 1.6μg/ml. Fluvirucin B2also inhibited PI-PLC in cultured A431 cells, whereas it did not inhibit phosphatidylinositol synthesis and macromolecular synthesis markedly. It also inhibited epidermal growth factor-induced rapid rounding of A431 cells, in which PI turnover is involved.

本文言語English
ページ(範囲)387-390
ページ数4
ジャーナルThe Journal of Antibiotics
48
5
DOI
出版ステータスPublished - 1995 1 1

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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