Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids

Fumiyuki Kiuchi, Satoshi Iwakami, Masaaki Shibuya, Fumio Hanaoka, Ushio Sankawa

研究成果: Article査読

304 被引用数 (Scopus)

抄録

The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylhepatanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis. This was verified by testing their inhibitory effects on 5-lipoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.

本文言語English
ページ(範囲)387-391
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
40
2
DOI
出版ステータスPublished - 1992
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

フィンガープリント

「Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル