Inhibition of Prostaglandin Biosynthesis by the Constituents of Medicinal Plants

Fumiyuki Kiuchi, Masaaki Shibuya, Takeshi Kinoshita, Ushio Sankawa

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Hot aqueous extracts of medicinal plants used in oriental medicine were tested for inhibitory effect on prostaglandin biosynthesis in order to detect biologically active compounds present therein. Of 162 samples tested, 35 showed significant inhibition. Inhibitors of prostaglandin biosynthesis contained in Cyperus rotundus were identified as sesquiterpenes. a-Cyperone, the main inhibitor of C. rotundus, showed competitive-type inhibition with respect to the substrate, arachidonic acid.

本文言語English
ページ(範囲)3391-3396
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
31
10
DOI
出版ステータスPublished - 1983
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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