The effect of intracerebroventricular injection of brain natriuretic peptide (BNP) on blood pressure and heart rate was studied in conscious, unrestrained rats. The intracerebroventricular (i.c.v.) injection of BNP did not affect basal blood pressure and heart rate, but it attenuated i.c.v. angiotensin II (AII)-induced pressor response in a dose-dependent manner. These results suggest that BNP plays a role in the regulation of blood pressure in the central nervous system.
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