Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats

Nakao Kazuwa, Katsuura Goro, Morii Narito, Itoh Hiroshi, Shiono Shozo, Sugawara Akira, Sakamoto Makoto, Saito Yoshihiko, Eigyo Masami, Yamada Takayuki, Sutsushita Akira, Hiroo Imura

研究成果: Article査読

50 被引用数 (Scopus)

抄録

The effects of intracerebroventricular injection of atrial natriuretic polypeptide (ANP) and angiotensin II (AII) on the concentration of dopamine, noradrenaline, serotonin and their primary metabolites in the rat brain were studied using high performance liquid chromatography with electrochemical detection. ANP (2 and 5 μg) decreased the level of dopamine and its metabolite in the septum and hypothalamus. In contrast, AII (100 ng) increased their levels in these brain regions. The simultaneous administration of ANP (5 μg) with AII (100 ng) resulted in a marked reduction of the AII-induced increase of dopamine and its metabolite. No significant changes were observed in the concentrations of noradrenaline and serotonin throughout the brain. These results suggest that the central action of ANP is mediated in part via the dopaminergic system.

本文言語English
ページ(範囲)171-177
ページ数7
ジャーナルEuropean journal of pharmacology
131
2-3
DOI
出版ステータスPublished - 1986 11月 19
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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