Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats

Nakao Kazuwa, Katsuura Goro, Morii Narito, Itoh Hiroshi, Shiono Shozo, Sugawara Akira, Sakamoto Makoto, Saito Yoshihiko, Eigyo Masami, Yamada Takayuki, Sutsushita Akira, Hiroo Imura

研究成果: Article

44 引用 (Scopus)

抜粋

The effects of intracerebroventricular injection of atrial natriuretic polypeptide (ANP) and angiotensin II (AII) on the concentration of dopamine, noradrenaline, serotonin and their primary metabolites in the rat brain were studied using high performance liquid chromatography with electrochemical detection. ANP (2 and 5 μg) decreased the level of dopamine and its metabolite in the septum and hypothalamus. In contrast, AII (100 ng) increased their levels in these brain regions. The simultaneous administration of ANP (5 μg) with AII (100 ng) resulted in a marked reduction of the AII-induced increase of dopamine and its metabolite. No significant changes were observed in the concentrations of noradrenaline and serotonin throughout the brain. These results suggest that the central action of ANP is mediated in part via the dopaminergic system.

元の言語English
ページ(範囲)171-177
ページ数7
ジャーナルEuropean journal of pharmacology
131
発行部数2-3
DOI
出版物ステータスPublished - 1986 11 19

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ASJC Scopus subject areas

  • Pharmacology

これを引用

Kazuwa, N., Goro, K., Narito, M., Hiroshi, I., Shozo, S., Akira, S., Makoto, S., Yoshihiko, S., Masami, E., Takayuki, Y., Akira, S., & Imura, H. (1986). Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats. European journal of pharmacology, 131(2-3), 171-177. https://doi.org/10.1016/0014-2999(86)90570-4