Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells

Taiko Oda, Jong Soo Lee, Yuta Sato, Yasuaki Kabe, Satoshi Sakamoto, Hiroshi Handa, Remy E P Mangindaan, Michio Namikoshi

研究成果: Article

13 引用 (Scopus)

抄録

N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare α-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-α production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited the mRNA level of mTNF-α, IκB-α degradation, and binding of NF-κB to the target DNA site in LPS-stimulated RAW 264.7 cells. Moreover, DDMG-1 had an inhibitory effect on the production of IL-8, which is produced in CD14 +-THP-1 cells stimulated by LPS. DDMG-1 is thus a promising drug candidate lead compound for the treatment of chronic inflammatory diseases, such as rheumatoid arthritis.

元の言語English
ページ(範囲)589-599
ページ数11
ジャーナルMarine Drugs
7
発行部数4
DOI
出版物ステータスPublished - 2009 12
外部発表Yes

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Lipopolysaccharides
Cytokines
Carbolines
Urochordata
Interleukin-8
Rheumatoid Arthritis
Chronic Disease
Macrophages
Messenger RNA
DNA
Pharmaceutical Preparations
RAW 264.7 Cells
N,N-didesmethylgrossularine-1

ASJC Scopus subject areas

  • Drug Discovery

これを引用

Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells. / Oda, Taiko; Lee, Jong Soo; Sato, Yuta; Kabe, Yasuaki; Sakamoto, Satoshi; Handa, Hiroshi; Mangindaan, Remy E P; Namikoshi, Michio.

:: Marine Drugs, 巻 7, 番号 4, 12.2009, p. 589-599.

研究成果: Article

Oda, Taiko ; Lee, Jong Soo ; Sato, Yuta ; Kabe, Yasuaki ; Sakamoto, Satoshi ; Handa, Hiroshi ; Mangindaan, Remy E P ; Namikoshi, Michio. / Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells. :: Marine Drugs. 2009 ; 巻 7, 番号 4. pp. 589-599.
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abstract = "N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare α-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-α production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited the mRNA level of mTNF-α, IκB-α degradation, and binding of NF-κB to the target DNA site in LPS-stimulated RAW 264.7 cells. Moreover, DDMG-1 had an inhibitory effect on the production of IL-8, which is produced in CD14 +-THP-1 cells stimulated by LPS. DDMG-1 is thus a promising drug candidate lead compound for the treatment of chronic inflammatory diseases, such as rheumatoid arthritis.",
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AU - Sato, Yuta

AU - Kabe, Yasuaki

AU - Sakamoto, Satoshi

AU - Handa, Hiroshi

AU - Mangindaan, Remy E P

AU - Namikoshi, Michio

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